A fitness trade-off between local competition and dispersal in Vibrio cholerae biofilms.

TitleA fitness trade-off between local competition and dispersal in Vibrio cholerae biofilms.
Publication TypeJournal Article
Year of Publication2011
AuthorsNadell CD, Bassler BL
JournalProc Natl Acad Sci U S A
Volume108
Issue34
Pagination14181-5
Date Published2011 Aug 23
ISSN1091-6490
KeywordsBiofilms, Biological Evolution, Biopolymers, Extracellular Space, Movement, Time Factors, Vibrio cholerae
Abstract

Bacteria commonly grow in densely populated surface-bound communities, termed biofilms, where they gain benefits including superior access to nutrients and resistance to environmental insults. The secretion of extracellular polymeric substances (EPS), which bind bacterial collectives together, is ubiquitously associated with biofilm formation. It is generally assumed that EPS secretion is a cooperative phenotype that benefits all neighboring cells, but in fact little is known about the competitive and evolutionary dynamics of EPS production. By studying Vibrio cholerae biofilms in microfluidic devices, we show that EPS-producing cells selectively benefit their clonemates and gain a dramatic advantage in competition against an isogenic EPS-deficient strain. However, this advantage carries an ecological cost beyond the energetic requirement for EPS production: EPS-producing cells are impaired for dispersal to new locations. Our study establishes that a fundamental tradeoff between local competition and dispersal exists among bacteria. Furthermore, this tradeoff can be governed by a single phenotype.

DOI10.1073/pnas.1111147108
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID21825170
PubMed Central IDPMC3161532
Grant ListR01 GM065859 / GM / NIGMS NIH HHS / United States
5R01GM065859 / GM / NIGMS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States